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Polyphenols

Polyphenols

Polyphenols

Osteoporosis: Soft Plums Harden Bone

Osteoporosis, or the softening of bones, is a major health problem amongst middle aged and elderly population groups in developed countries. The fundamental cause of this degenerative disease is still somewhat uncertain and the common preventive advice given by health professionals and dieticians is to eat plenty of calcium rich foods such as dairy products.

Although hormonal changes in later life are known to have an influence on bone softening (as is the lack of gravity-resistance exercise such as walking, jogging or weight lifting) these factors alone cannot explain the increasing incidence of this serious disease.

Bone is an active, living tissue that is being formed, remodeled and shaped continuously in response to both physical and physiological influences on the body. Bone matrix consists primarily of calcium, magnesium and phosphate and is the material that makes up both the dense parts of the bone and the bone marrow framework.

Many people still believe that if one eats foods rich in these minerals and sufficient vitamin D then they will avoid developing osteoporosis. Epidemiological data suggest that this is not the case.

When it comes to bone health and disease the integrated processes that control its formation and resorption are just as important as the availability of vitamin D, calcium, magnesium and phosphate.

As mentioned earlier bone is a dynamic tissue the matrix of which is controlled by two main cell types: osteoblasts are bone cells that are responsible for the FORMATION of bone matrix while osteoclasts are modified white blood cells responsible for the RESORPTION of bone tissue.

These two cell types are controlled by a complex set of signaling hormones and proteins that respond according to the ever-changing physiological and pathological demands on bone tissue. If there are too many osteoclasts, or if these cells become overactive, they will resorb more matrix than the osteoblasts can produce. A predominance of osteoclast activity results in the bone becoming less dense - the principal characteristic of the clinical condition known as osteoporosis.

Osteoporosis is a disease characterized by the de-mineralization of bone matrix and may be associated with several specific diseases (such as hyperparathyroidism) and the long-term use of drugs such as corticosteroids. However the majority of those who develop osteoporosis DO NOT suffer from any of these diseases and generally have adequate intakes of calcium, vitamins and exhibit normal hormone profiles.

PHYTONUTRIENT DEFICIENCY IS A CAUSE OF OSTEOPOROSIS

There is more and more evidence to show that the principal cause of age-related osteoporosis is actually a deficiency of non-vitamin phytonutrients.

Epidemiological studies have shown that rural Chinese peasants who eat very little meat and dairy produce have extremely low incidences of osteoporosis. Moreover, their diets are rich in a wide variety of plant foods that provide high levels of polyphenols and other bioactive plant compounds as well as adequate amounts of calcium, magnesium and phosphate.

Recent research carried out by scientists at the Department of Nutritional Sciences, Oklahoma State University shows that polyphenols from plums have a strong influence on the signaling mechanisms that control bone formation. Polyphenols are a group of compounds that give plants their rich colours and are therefore particularly prevalent in deeply coloured foods such as plums, berries and certain spices.

Although scientists have previously found that polyphenols help prevent a number of other degenerative diseases this is the first time they have been found to be of benefit in osteoporosis.

The researchers at Oklahoma State University discovered that, even in the presence of oxidative stress and systemic inflammation, polyphenols work directly on the signaling mechanisms that control bone metabolism. Their impact on these vital systems results in the inhibition of the bone-softening osteoclasts while enhancing the generation and activity of bone-building osteoblasts.

This fresh research is further confirmation of the importance of plant based phytonutrients to human health. These non-vitamin micronutrients have been shown to help many other conditions such as Alzheimer's disease, heart disease, cancer, macular degeneration, diabetes and other degenerative diseases.

Several pathological processes such as oxidative stress and low-grade systemic inflammation are common to these diseases and accelerate aging. Similarly the development of osteoporosis is aggravated by oxidative stress and inflammation.

Since plant based antioxidants and other bioactive compounds have been shown to help the most prevalent of our degenerative conditions it is gratifying to know that one of the solutions to preventing yet another of these debilitating conditions is simply to eat more fruits (such as plums) and other foods (such as spices) that contain large quantities of bone strengthening polyphenols and related disease-fighting phytonutrients.

REFERENCES:

1. Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I J Nutr Biochem. 2009 Jan;20(1):35-44. Epub 2008 May 20. Bu SY, Hunt TS, Smith BJ

2. Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATc1 and inflammatory mediators.Calcif Tissue Int. 2008 Jun;82(6):475-88. Bu SY, Lerner M, Stoecker BJ, Boldrin E, Brackett DJ, Lucas EA, Smith BJ.

3. Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic Biol Med. 2006 May 1;40(9):1483-93. Epub 2005 Dec 9. Kim HJ, Chang EJ, Kim HM, Lee SB, Kim HD, Su Kim G, Kim HH.

4.(Book)The China Study: The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss and Long-term Health by T. Colin Campbell Thomas M. Campbell II Howard Lyman

ChemCorner: Polyphenols in tea


Maximum Strength Apple Polyphenols 125 Mg 60 Caps
Maximum Strength Apple Polyphenols 125 Mg 60 Caps
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Try the natural health-enhancing power of apples in a convenient capsule form with Swanson Ultra Maximum Strength Apple Polyphenols! Apples are rich in natural antioxidant compounds known as polyphenols. These powerful protectors not only work to neutralize harmful free radicals, they also provide effective support for healthy respiratory function, seasonally and year-round.

Features

  • Seasonal and year-round respiratory aid
  • Knocks out harmful free radicals
  • 125 mg of powerful polyphenols per capsule
Good N Natural - Standardized Green Tea Extract 500 mg (800 mg Polyphenols, 350mg EGCG) - 120 Caps
Good N Natural - Standardized Green Tea Extract 500 mg (800 mg Polyphenols, 350mg EGCG) - 120 Caps
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Green Tea is a nutritional staple in Japan where is has been used for centuries for its beneficial properties. The polyphenols within Green Tea are believed to be primarily responsible for the herb's positive actions on cardiovascular health and immune function. Our Green Tea extract is standardized for 80% polyphenols, one of the active constituents in this herb. Polyphenols such as EGCG are powerful antioxidants that help fight against cell-damaging free radicals in the body. By scientifically isolating active constituents, we ensure that they remain at consistent concentration levels with each does.

Features

  • Good N Natural - Standardized Green Tea Extract 500 mg (800 mg Polyphenols, 350mg EGCG) - 120 Caps
Polyphenol Nutrients 360 capsules - 360 - Capsules
Polyphenol Nutrients 360 capsules - 360 - Capsules
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Please remember to take 15% off from MSRP for Internet Customers when adding the product to their order. *Tax applies to Washington State Residents.

Features

  • Packed with flavonoids and phenolic compounds from a unique blend of olive fruit, grape seed, pomegranate, green tea, quercetin and blueberry, this formula offers powerful overall cellular protection.
  • Contains the protective nutrients alpha lipoic acid, NAC, inositol and choline to complement the neural, cognitive, cardiovascular, liver and skin health properties of this diverse profile.
  • Polyphenol Nutrients provides the advanced mineral delivery systems and active vitamin cofactors found in Nutrient 950® and UltraNutrient® for optimal bioavailability and utilization.
  • As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6 and vitamin B12 may reduce the risk of vascular disease.
  • Polyphenol Nutrients is a nutrient dense multivitamin and mineral formula enhanced with an exceptional combination of polyphenols and specialized compounds for extensive physiological protection.
My Beauty Diary Mask - Apple Polyphenol 10pcs
My Beauty Diary Mask - Apple Polyphenol 10pcs
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Contains removes dead cells of skin, improves and prevents enlarged poresHyaluronic acid - stimulates synthesis of collagen, improves skin's firmness and resilienceGentle nano - AHAs prolong pore-contracting effects

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  • Moisturizing, smoothing, firming for use on normal skin
  • Especially recommended for skin with enlarged pores
Pure Encapsulations- Polyphenol Nutrients 360 Vcaps [Health and Beauty]
Pure Encapsulations- Polyphenol Nutrients 360 Vcaps [Health and Beauty]
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Jarrow Formulas Bilberry and Grapeskin Polyphenols 280mg, 60 Capsules
Jarrow Formulas Bilberry and Grapeskin Polyphenols 280mg, 60 Capsules
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Jarrow Formulas Bilberry + Grapeskin Polyphenols is a synergistic blend of flavonoid antioxidants.Swedish Bilberries (100:1) contain 25% polyphenols as anthocyanosides. Red Grapeskin contains 30% polyphenols including 4% anthocyanins.Bilberry flavonoids support and protect vision by enhancing antioxidant status in the eye and reducing capillary permeability and fragility.

Features

  • Innovative - will enhance your well being.
Polyphenol Nutrients 180 capsules - 180 - Capsules
Polyphenol Nutrients 180 capsules - 180 - Capsules
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Description

Please remember to take 15% off from MSRP for Internet Customers when adding the product to their order. *Tax applies to Washington State Residents.

Features

  • Powerful polyphenol-rich multivitamin and multimineral formula with additional protection factors
  • Packed with flavonoids and phenolic compounds from a unique blend of olive fruit, grape seed, pomegranate, green tea, quercetin and blueberry, this formula offers powerful overall cellular protection
  • It also contains the protective nutrients alpha lipoic acid, NAC, inositol and choline to complement the neural, cognitive, cardiovascular, liver and skin health properties of this diverse profile.
  • Polyphenol Nutrients provides the advanced mineral delivery systems and active vitamin cofactors found in Nutrient 950® and UltraNutrient® for optimal bioavailability and utilization.
  • As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6 and vitamin B12 may reduce the risk of vascular disease.
Alternative Health & Herbs Remedies Grape Seed 95% Polyphenols ( Standardized Extract) Capsules, 90-Count Bottle
Alternative Health & Herbs Remedies Grape Seed 95% Polyphenols ( Standardized Extract) Capsules, 90-Count Bottle
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WILD YAM (Dioscorea villosa) is an anti-inflammatory, antispasmodic, blood purifier, and diaphoretic. Relaxes muscles, soothes nerves, and relieves pain. Good as a uterine tonic. Helps prevent miscarriage. Contains progesterone-like compounds. Its traditional use is for easing menstrual cramps and for the prevention of miscarriage. It is a uterine tonic during pregnancy. Small frequent doses during pregnancy may help to alleviate nausea. Its antispasmodic property is beneficial for allaying colic and flatulence caused by muscle spasms; for poor circulation and neuralgia; for the inflammatory stage of rheumatory arthritis; and for abdominal and intestinal cramping. It is very beneficial for nervousness, restlessness and other nervous conditions. As a stimulant for increased bile flow, it helps to relieve hepatic congestion, bilious colic and gallstones.

Nature's Plus Ultra Acai 1200 mg / 120 mg Polyphenols Extended Release 30 bi-layered tablets
Nature's Plus Ultra Acai 1200 mg / 120 mg Polyphenols Extended Release 30 bi-layered tablets
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Standardized Botanical Supplement Prescription Quality

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  • 1200 mg / 120 mg Acai Polyphenols
Green Tea Extract, 400mg, 90 Veg Capsules (Standardized to 98% Polyphenols, 50% EGCG)
Green Tea Extract, 400mg, 90 Veg Capsules (Standardized to 98% Polyphenols, 50% EGCG)
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Green Tea Extract Green tea has been used for over 5,000 years for pain, digestion, mood maintenance, immune enhancement, detoxification, energy enhancement, and anti-aging. Unlike black and oolong teas, green tea does not endure a fermentation process and thus retains a host of beneficial phytonutrients. Specifically, green tea contains high concentrations of polyphenols ? plant-derived antioxidant compounds linked to health benefits ranging from immune system support to cardiovascular health. The primary polyphenols found in green tea include four catechins -- epigallocatechin gallate (EGCG) being the most potent and extensively researched. As an antioxidant, EGCG ranks up there with ascorbate (vitamin C) and glutathione, and helps move carcinogens and invading bacteria out of the body! EGCG ? Supporting the Immune System & More Since the 1970s, epidemiological studies have shown that in parts of the world where green tea is consumed, the incidence of solid tumor cancers -- such as breast, lung and gastrointestinal cancer -- is lower. Green Tea has garnered the attention of the National Cancer Institute and many other research initiatives . Cardiovascular, Nervous System & Bone Density Support Green tea?s heart health benefits stem from its anti-inflammatory effect on cells, its ability to spur the production of nitric oxide, which acts to keep blood vessels relaxed and blood pumping efficiently. Green tea has also shown promise with regard to neurological and brain health by scavenging free-radicals and supporting healthy neuron function . In addition to its well-known heart health benefits, green tea?s flavonoids and phytoestrogens support bone mineral density. Green tea may also inhibit bone resorption (the breaking down of bones and release of bone minerals into the blood stream, altogether too common in aging). Energy Efficiency and Calorie Burning Everyone seems to be interested in weight loss these days, so ?thermogenic?

Features

  • Green tea has been used for over 5,000 years for pain, digestion, mood, detox, and energy support
  • Green tea contains high concentrations of polyphenols a plant-derived antioxidant
  • Our supplement contains Green tea extract 400mg,and EGCg a powerful antioxidant 200mg,
  • Green tea suppors thermogenic activity helping the body with more efficient fat burning potential
  • Green tea?s flavonoids and phytoestrogens support bone mineral density
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